AnHorn Medicines is a dynamic drug discovery company focusing on the development of next-generation targeted protein degradation therapies. AnHorn’s AI-platform enables for the discovery of more drug-like, orally bioavailable protein degraders.
AnHorn Medicines is currently seeking a highly motivated and team-oriented candidate for the position, in the Department of Drug Metabolism and Pharmacokinetics (DMPK). The successful candidate will support ADME/PK activities on one or more discovery project teams, facilitating the identification and development of small molecule cancer therapeutics.
Roles and Responsibilities
•Serve as DMPK subject matter expert on cross-functional teams, providing in vitro and in vivo drug disposition data, interpretation, and presentations
•Assist in the design and coordination of in vivo PK studies in laboratory animals
•Develop LC-MS or LC-MS/MS methods and perform bioanalysis for in vitro and in vivo biological samples
•Perform PK data analysis and interpret results in relation to in vitro ADME data and PK data for compound analogs
•Design and conduct in vitro experiments in liver microsomes or hepatocytes to generate compound metabolites, characterize metabolic pathways, evaluate metabolism kinetics, determine bioactivation mechanisms, etc.
•Identify metabolites from mass spectral data and further characterize potentially pharmacologically active or reactive metabolites
•Provide guidance on chemical modifications that may improve ADME properties
•Prepare documents to support regulatory IND filings
•Evaluate new technology and methodology that advances our understanding of ADME/PK, target-engagement, etc.
•Routinely prepare and present data with competitor differentiation in support of Business Development activities
•MS or Ph.D. degree in pharmacokinetics, drug metabolism, biochemistry, chemistry or other relevant fields
•Candidate should have fundamental understanding of various DMPK areas such as physicochemical properties, PK, drug metabolizing enzyme and transporter kinetics, and mechanisms of bioactivation
•Hands-on experience and strong trouble shooting skills for LC-MS or LC-MS/MS bioanalysis
•The candidate should have extensive experience interpreting mass spectral data to make structural assignments
•Experience with non-compartmental PK analysis
•Excellent oral and written communication skills
•Excellent interpersonal skills and ability to work in a team environment
AnHorn is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.